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KMID : 0364320200450020031
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Journal of East-West Medicine
2020 Volume.45 No. 2 p.31 ~ p.35
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Review concerning the role of lateral hypothalamus in the inhibitory effects of acupuncture on drug addiction
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Ahn Dan-Bi
Kim Hee-Young
Choi Seong-Hun
Lee Sang-Nam
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Abstract
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OBJECTIVES : Acupuncture has been used to treat substance abuse. Our previous studies have shown that acupuncture suppresses drug self-administration behavior or relapse to abused drugs. The central mechanism underlying acupuncture's role in suppressing the reinforcing effects of abused drugs includes modulation of the ventral tegmental area (VTA), the nucleus accumbens (NAc) and hypothalamus. In particular, this review focused on the role of lateral hypothalamus in acupuncture inhibition of drug addiction. As it is known that lateral hypothalamus is one of the important areas involved in sensory modulation and addiction, it may be necessary to understand role of lateral hypothalamus in acupuncture effects. We report that the lateral hypothalamus may critically contribute to acupuncture effects on addiction behaviors.
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KEYWORD
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Acupuncture, hypothalamus, lateral hypothalamus, drug, reward
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